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The Protective Effect of Echinops spinosus Alcohol Extract on Toxicity Induced by The Administration of Repeated Deep-Fried Oil in Experimental Rats |
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PP: 11-25 |
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Author(s) |
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Yasmeen M. Zeed,
Neveen M. Zeima,
Amira M. ElMoslemany,
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Abstract |
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| The present work aimed to assess the impact of Echinops spinosus L. (ES) alcohol extract
on the toxicity caused by the repeated administration of deep-frying oil (RDFO) in
experimental rats. A phenolic bioactive compound of ES was quantified using HPLC.
Group (I) rats (negative control) were fed a basal diet. Group (2) rats were fed a basal diet
and gavaged 200 mg/kg b.w. of ES extract. Group (3) rats (positive control) were fed a
basal diet and given (RDFO) at a dose of 5 g/kg b.w. Group (4) rats were fed a basal diet
and given 200 mg/kg b.w. of ES extract+ (RDFO) at a dose of 5 g/kg for 35 days. Body
weight gain (BWG), feed intake (FI), feed efficiency ratio (FER), and relative weight of the
kidneys, liver, and heart were estimated. Analysis was conducted on serum biochemical
parameters and antioxidant/oxidant markers. Aspartate aminotransferase (AST), alanine
aminotransferase (ALT), γ-glutamyl transferase, creatinine, urea, uric acid, lactate
dehydrogenase (LDH), creatine Kinase-MB (CK-MB), total cholesterol, triglycerides,
fasting blood glucose, malonaldehyde (MDA), and nitric oxide (NO) were elevated by the
administration of (RDFO). The adverse effects caused by repeated exposure to deep oil
were improved by administering ES alcohol extract to rats. These findings indicate that
ES extract may have a beneficial effect on the toxicity caused by the administration of
(RDFO). In conclusion, the administration of ES alcohol extract can enhance the effects of
(RDFO) administration on rats. |
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