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International Journal of Advanced Biomedicine



Overview of HCC; Data Mining Discovery (Multi-Center Study)

Mohamed Younis, Abdallah Nawara, Elsayed A.Elgohary, Mohammad M. Sallam, Ali Ismael, Abd Elrazek Abd Elrazek, Hamdy Mahfouz,
Abstract :
Background and Aim: Hepatocellular carcinoma is one of the most aggressive cancers that represent a global health problem. It is the fifth most common cancer and the second most common cause of cancer related- mortality worldwide. Hence we conducted the current study using high performance- data mining technology to obscure hidden knowledge would be helpful guide for better predication, follow up and best management. Patients and Methods: Retrospectively, 130 Egyptian patients presented with HCC were followed clinically and their data were analysed using high performance technology of data mining intellectual machine learning of Raid I software program. Results: Amazing results were obtained using Knowledge discovered by data (KDD) such as Serum Creatinine and Total Bilirubin should be the best laboratory indicators for HCC progression. AFP may increase not for the HCC itself but for progression cirrhosis. Furthermore HCC biology should be considered than multiplicity. Conclusion: HCC still a major medical concern in Egypt. Data mining programs would be very helpful in such an area of oncology and future medicine.


Hematological Studies In Egyptian Children With Acute Lymphoid And Myeloid leukemia

Ahmed Samy El-Shafey,
Abstract :
Hematological Studies In Egyptian Children With Acute Lymphoid And Myeloid leukemia Ahmed S. El-Shafey*1, Saida M. Amer1, Nanis G. Allam1 and Mohsen S. El-Alfy2 1 Microbiology Section, Faculty of Science, Tanta University 2 Hematology & Oncology unit, Pediatrics Department, Faculty of Medicine, Ain shams University *1 Corresponding author: E-mail: ahmedsamymmd@gmail.com Abstract Introduction: Acute leukemia is the most common form of childhood cancer and is the primary cause of cancer-related mortality in children. Material and methods: Complete blood count investigations were done to patients with acute leukemia and healthy control by manual method. Results; A significant decrease in hematological parameters as total leucocytes count, hemoglobin, Red blood cell count, platelets count, hematocrit and neutrophils percent during chemotherapy compared to before chemotherapy as action of chemotherapy Conclusion; This study proved that children with acute leukemia suffered from leucopenia, anemia, and thrombocytopenia during chemotherapy that made them susceptible to infections and bleeding complications.


Can Variceal Band Ligation (VBL) Improve MELD Score for patients awaiting for liver transplantation?

Ali Ismael, Elsayed A. El Gohary, Abdallah Nawara, Mohammad M. Sallam, Khaled Abdel-Azeem, Abd Elrazek Abd Elrazek,
Abstract :
Background: Esophago-gastric varices are abnormal distended veins usually seen in the esophagus (esophageal varices) and less commonly in the stomach (gastric varices) or in other sites (ectopic varices), bleeding such varices prior to liver transplantation may increase the MELD associated co-morbidities and even mortalities, hence Liver operation may cancelled in different situations, Nevertheless (VBL) should be optimized critically to improve overall success. Aim: Evaluated prophylactic (VBL) may have a beneficial role improving MELD score for those awaiting for Liver Transplantation. Methods: prospectively 70 patients; 53 male and 17 female awaiting for liver transplantation aged (18 to 63) year- old (MELD score ranged between 16 to 38, presented with esophageal/ gastric varices with different grades, VBL was done as primary prophylaxis and comparative MELD score was calculated at the time of VBL and 2 weeks further on. Children was excluded from the study, additionally patients beyond Milan HCC criteria and those with contraindication for major surgery were excluded also. Results: MELD score improved post VBL without reported complications, additionally VBL as a primary prophylaxis was a corner stone procedure saving those with large varices against bleeding may affect the overall operation prognosis, Mean, Median and SD before and after VBL was; (18.9,19.2, 6.02) and (16.9,15.9,6.5) respectively. Conclusion: Cirrhotic patients presented with large esophageal varices (LEVs) prepared for liver transplantation should receive variceal band ligation (VBL) prior to surgery, should decrease associated co-morbidities. MELD score have been improved totally post (VBL), but statistically showed no significant importance.


Hyperthermic effects of cobalt ferrite nanoparticls on adipose cells

R. A. Hassan,
Abstract :
Abstract: Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological to damage and kill cells. Magnetic nanoparticles possess unique properties which can be applied in nanomedicine, they address targets such as cellular therapy, tissue repair, nanobiosensors, drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. In this work, cobalt ferrite nanoparticls (CFNP) were selectively synthesized with narrow size distribution using chemical precipitation methods. The obtained powder was calcined at 600 C. The sample which characterized by Transmission Electron Microscopy (TEM)confirmed the formation of single-phase CFNP in the range 1025 nm. Localized magnetic particle hyperthermia treatment using ferrimagnetic nanoparticles continue to be an active area of medical research. So, homemade induction heater was designed. The coil was designed to be capable of generating high frequency, strong alternative magnetic fields. The CFNP hyperthermia application in medical was in vitro studied using samples of rabbits Subcutaneous adipose cells. The adipose cells microscopic imaging data as well as the bio distribution results of hyperthermic CFNP content sample showing decreasing the number of subcutaneous adipocyte cell by 23.9 %. In conclusion the preliminary new results for nanoparticles bearing a CFNP core justify further investigations towards potential hyperthermia slimming applications.


Suulphonylurea, Metformin, TZDs: Potential drugs to cure Diabetes

Kamlesh Kumari,
Abstract :
This review introduces the disease state of diabetes mellitus and provides a background of the impact of the disease on the population, its biology and pathophysiology, and the current treatment strategies for treating diabetes. In Europe, the thiazolidinedione derivatives pioglitazone and rosiglitazone have been approved for the treatment of type 2 diabetes mellitus either as monotherapy for patients with intolerance or contraindications to metformin or in combination therapy. Modifications of thiazolidinediones have proven highly effective and do not exhaust the possible changes that can be made to improve potency, safety and efficacy of these thiazolidinedione derivatives. TZDs have been approved for type 2 diabetes mellitus, particularly for overweight patients who are inadequately controlled by diet and exercise alone, for which metformin and sulphonylurea are inappropriate because of contraindications or intolerance. This class of drugs seems particularly suited for obese patients, but is currently not considered as a first choice for monotherapy. The efficacy with respect to blood glucose lowering is comparable with sulphonylurea (SU) derivatives and with metformin. Long-term data with respect to efficacy and side effects are still limited. This is the updated report on thaizolidinediones and explained its efficacy and how it is better than other antidiabetic agents.


Understanding the Quality of Life (QoL) and Quality Adjusted Survival (QAS) in Children, Teens and Young Adults with Cancer.

Hisham Morsi, Jon Perkins, Abdulkafi Al Saied, Azza Hassan, Caroline langford, Eliaas Alemayehu, Holy Clark, Aya Asharaf, Mohammed Abulaban,
Abstract :
The Quality of Life Group is typically a collection of oncology specialists, psychologists and support workers dedicated to improving the Quality of Life (QoL) of paediatric, adolescent and young adult cancer patients. The Group usually aims at improving patient care by: Identifying areas where patients are suffering. Identifying areas where service provision is lacking. Direct patients towards appropriate intervention(s). Educate health practitioners about the whole needs of the patient. Support family and friends so that they can play an active role in patient care. Develop and administer interventions that improve QoL. Coordinate allied healthcare and community support professionals to build a coherent, patient-focused, support network for patients and their families.


Personalised cancers treatment for Children, Teenagers and Young Adults (CTYA).

Hisham Morsi,
Abstract :
Cancer treatment has gone through several decades of treatment strategies of phase I, phase II and randomized controlled trials until reaching the current phase of successful treatment that approaches >95% cure rates in some paediatric based chemotherapy protocols. However some diseased are still not curable despite the use of combinations of surgery, chemotherapy, radiotherapy, immunotherapy, hormonal treatments, biological modifiers, novel agents and stem cell transplants (autologous and allogeneic). Such diseases are demanding alternative approaches and hence the oncology community is heading towards personalized management approaches. Here we present an overview of the precise medications approaches that have been tried by different teams. The near future would include combinations of these approaches to gain better understanding of the disease and achieve better outcomes.

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