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International Journal of Advanced Biomedicine



Can We Consider H. Pylori as A Risk Factor for Acute Coronary Syndrome? A Proposal Study for A Sample of Egyptian Population

Khaled Salma, Abd-Elrazek Abd-Elrazek,
Abstract :
Helicobacter pylori (H. pylori) is a Gram negative spiral bacterium which colonizes gastric mucosa of nearly half of human populationwas described by Marshall and Warren in 1984 . A characteristic feature of H. Pylori infection is an excessive inflammatory response. The majority of H. pylori infections remain asymptomatic. However, still it leads to the development of histological gastritis with the recruitment of immune cells. About 10% of infected subjects develop symptomatic gastritis, erosions or peptic ulcer. Gastric cancer is the most severe consequence of H. pylori infection. Recently, a possible association between chronic infections with H. pylori and extragastric disorders - including coronary heart disease, has been intensively investigated. Here we will shed light on a possible association between chronic H.Pylori infection and one of the commonest Heart disease; Acute Coronary Syndrome (ACS).


Is there a role of Helicobacter Pylori infection in Incidence of Acute Coronary syndrome?

Ramadan Ghaleb, Hossam Mansour, Mohamed Omar Amer, Ali Ismael, Akshaya Srikanth Bhagavathula, Abd Elrazek Abd Elrazek,
Abstract :
Background: There is a growing interest in the bacterium’s association in extragastric diseases such as cardiovascular, neurological, hematological and uro-gynecological diseases. Aim: We aimed to investigate the correlation between acute coronary syndrome (ACS) and chronic infection of Helicobacter pylori (H.pylori) in Egyptian population. Methods: We prospectively evaluated 119 patients (from December 2016- February 2017) presented with typical chest pain and/or percutaneous coronary intervention revealed ACS are investigated to H.Pylori infection by antibodies (Ab) test of both acute and chronic infection. IgM and IgG tests respectively to evaluate the association between ACS and H.pylori infection. Univariable and multivariable Cox proportion hazards regression with a 95% confidence interval (CI) was used to measure the crude hazard ratio (HR) and adjusted HR (aHR) of ACS for the H.pylori infection. Results: The mean age of the study population was 57.9 ±11.2 [standard deviation (SD)] and having comorbidities like diabetes (46.2%), and hypertension (42%). ACS was confirmed in 94% of the whole study sample with H.pylori IgG antibodies (mean±SD: 2.36± 1.42 U/mL). The risk of developing ACS was significantly associated and increased with increasing age. The risk of developing ACS in patients with higher H.pylori IgG was 1.6 times (95% CI: 0.662-1.704). We also estimated the risk of ACS in relation to family history, the risk of developing ACS was nearly two-fold higher in patients with existence of family history of CVDs. Conclusion: However there are many presented with ACS, current risk factors cannot explain their ACS, hence chronic H. Pylori infection may play a role, need further researches evaluate the real condition.


Overview of HCC; Data Mining Discovery (Multi-Center Study)

Mohamed Younis, Abdallah Nawara, Elsayed A.Elgohary, Mohammad M. Sallam, Ali Ismael, Abd Elrazek Abd Elrazek, Hamdy Mahfouz,
Abstract :
Background and Aim: Hepatocellular carcinoma is one of the most aggressive cancers that represent a global health problem. It is the fifth most common cancer and the second most common cause of cancer related- mortality worldwide. Hence we conducted the current study using high performance- data mining technology to obscure hidden knowledge would be helpful guide for better predication, follow up and best management. Patients and Methods: Retrospectively, 130 Egyptian patients presented with HCC were followed clinically and their data were analysed using high performance technology of data mining intellectual machine learning of Raid I software program. Results: Amazing results were obtained using Knowledge discovered by data (KDD) such as Serum Creatinine and Total Bilirubin should be the best laboratory indicators for HCC progression. AFP may increase not for the HCC itself but for progression cirrhosis. Furthermore HCC biology should be considered than multiplicity. Conclusion: HCC still a major medical concern in Egypt. Data mining programs would be very helpful in such an area of oncology and future medicine.


Hyperthermic effects of cobalt ferrite nanoparticls on adipose cells

R. A. Hassan,
Abstract :
Abstract: Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological to damage and kill cells. Magnetic nanoparticles possess unique properties which can be applied in nanomedicine, they address targets such as cellular therapy, tissue repair, nanobiosensors, drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. In this work, cobalt ferrite nanoparticls (CFNP) were selectively synthesized with narrow size distribution using chemical precipitation methods. The obtained powder was calcined at 600 °C. The sample which characterized by Transmission Electron Microscopy (TEM)confirmed the formation of single-phase CFNP in the range 10–25 nm. Localized magnetic particle hyperthermia treatment using ferrimagnetic nanoparticles continue to be an active area of medical research. So, homemade induction heater was designed. The coil was designed to be capable of generating high frequency, strong alternative magnetic fields. The CFNP hyperthermia application in medical was in vitro studied using samples of rabbits Subcutaneous adipose cells. The adipose cells microscopic imaging data as well as the bio distribution results of hyperthermic CFNP content sample showing decreasing the number of subcutaneous adipocyte cell by 23.9 %. In conclusion the preliminary new results for nanoparticles bearing a CFNP core justify further investigations towards potential hyperthermia slimming applications.

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