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International Journal of Advanced Biomedicine



Is there a role of Helicobacter Pylori infection in Incidence of Acute Coronary syndrome?

Ramadan Ghaleb, Hossam Mansour, Mohamed Omar Amer, Ali Ismael, Akshaya Srikanth Bhagavathula, Abd Elrazek Abd Elrazek,
Abstract :
Background: There is a growing interest in the bacterium’s association in extragastric diseases such as cardiovascular, neurological, hematological and uro-gynecological diseases. Aim: We aimed to investigate the correlation between acute coronary syndrome (ACS) and chronic infection of Helicobacter pylori (H.pylori) in Egyptian population. Methods: We prospectively evaluated 119 patients (from December 2016- February 2017) presented with typical chest pain and/or percutaneous coronary intervention revealed ACS are investigated to H.Pylori infection by antibodies (Ab) test of both acute and chronic infection. IgM and IgG tests respectively to evaluate the association between ACS and H.pylori infection. Univariable and multivariable Cox proportion hazards regression with a 95% confidence interval (CI) was used to measure the crude hazard ratio (HR) and adjusted HR (aHR) of ACS for the H.pylori infection. Results: The mean age of the study population was 57.9 ±11.2 [standard deviation (SD)] and having comorbidities like diabetes (46.2%), and hypertension (42%). ACS was confirmed in 94% of the whole study sample with H.pylori IgG antibodies (mean±SD: 2.36± 1.42 U/mL). The risk of developing ACS was significantly associated and increased with increasing age. The risk of developing ACS in patients with higher H.pylori IgG was 1.6 times (95% CI: 0.662-1.704). We also estimated the risk of ACS in relation to family history, the risk of developing ACS was nearly two-fold higher in patients with existence of family history of CVDs. Conclusion: However there are many presented with ACS, current risk factors cannot explain their ACS, hence chronic H. Pylori infection may play a role, need further researches evaluate the real condition.


Hyperthermic effects of cobalt ferrite nanoparticls on adipose cells

R. A. Hassan,
Abstract :
Abstract: Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological to damage and kill cells. Magnetic nanoparticles possess unique properties which can be applied in nanomedicine, they address targets such as cellular therapy, tissue repair, nanobiosensors, drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. In this work, cobalt ferrite nanoparticls (CFNP) were selectively synthesized with narrow size distribution using chemical precipitation methods. The obtained powder was calcined at 600 °C. The sample which characterized by Transmission Electron Microscopy (TEM)confirmed the formation of single-phase CFNP in the range 10–25 nm. Localized magnetic particle hyperthermia treatment using ferrimagnetic nanoparticles continue to be an active area of medical research. So, homemade induction heater was designed. The coil was designed to be capable of generating high frequency, strong alternative magnetic fields. The CFNP hyperthermia application in medical was in vitro studied using samples of rabbits Subcutaneous adipose cells. The adipose cells microscopic imaging data as well as the bio distribution results of hyperthermic CFNP content sample showing decreasing the number of subcutaneous adipocyte cell by 23.9 %. In conclusion the preliminary new results for nanoparticles bearing a CFNP core justify further investigations towards potential hyperthermia slimming applications.

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