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The Role of γ-Irradiated Zinc oxide Nano-particles as a Treatment to Improve Burn Healing in Male Albino Rats |
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PP: 265-275 |
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doi:10.18576/jrna/090310
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Author(s) |
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H. M. Essam,
Salwa N.A,
Mater, I. A. Ali,
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Abstract |
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| Chemical Burn accidents happen on a daily basis, especially when it comes to chemical cleaners. Most chemical used for cleaning are extremely irritant or even sometime dangerous to the user’s skin. Zinc oxide is well known remedy for skin burns as well as a component in an array of other cosmetics. Nanoparticulation is a growing technology that aims at, in part, to improve drug kinetics and to target its content to the coveted organ. The main aim of the present study is to investigate the impact of nanoparticulation of zinc oxide followed by γ- irradiation on its ability to promote healing of partial-thickness burns model in male rats. Male Albino rats were categorized into four groups; G1 were the control group while partial thickness burns were induced in G2, G3 and G4. G2 were topically treated with pure paraffin, whereas G3 and G4 were topically treated with ordinary zinc oxide ointment, and irradiated nano-zinc oxide ointment respectively. Burn healing was examined over seven weeks of burn induction in all groups. The data from the present study showed that topical application of γ- irradiated nano-zinc oxide is superior to non-nano particulate zinc oxide ointment in the recovery from partial burn thickness in albino male rats. |
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