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Effect of Endurance Training on Homocysteine Level in Elderly with Megaloblastic Anemia |
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PP: 97-103 |
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doi:10.18576/ijtfst/120203
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Author(s) |
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Amir Abdel Moaty Serag,
Nesreen Ghreeb Al Nahas,
Gehan Mohamed Shaera,
Azza Abdel Aziz Abdel Hady,
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Abstract |
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| Background: Vitamin B12 deficiency causes megaloblastic anemia and it’s a major contributor to hyper-homo- cysteinemia which have been linked to the risk of vascular disease, stroke, and dementia and are relatively common in elderly. Aim of Study: To investigate effect of endurance training program on homocysteine level in elderly patients with megaloblastic anemia. Methods: Sixty elderly patients suffered from megaloblastic anemia, participated in this study were selected randomly from out-patient clinic of internal medicine in Sers Ellyan hospital with age mean ± SD values in groups (A) and (B) were 68.23±2.74 and 67.83±2.19 years, respectively. The study design was pre-post study. Patients were assigned for 16 weeks protocol into two equal groups: Group (A) (study group): received selected endurance training 3 times a week for 16 weeks with controlled dietary vitamin B12 intake, while Group (B) (control group): received only B12 supplementation. The outcome measures were serum vitamins B12, total homocysteine (tHcy), mean corpuscle volume, 10MWT test and physical characteristic (weight and body mass index (BMI)) were evaluated at the baseline and the end of the study in both groups. Results: Pre- and post-treatment comparisons showed a statistically significant increase of the measured variables in the group A (serum B12 47.68%, 10MWT 40.86%) and significant decrease in MCV 15.62%, tHcy 28.93%. Group B showed a statist
(serum B12 134.76%, 10MWT 8.33% and significant decrease in MCV 17.97% and tHcy 37.31%). There were significantly higher change differences in the study group regarding dietary B12 and 10MWT compared to the control group (P<0.001 for all), a significantly lower change was observed in serum B12 and tHcy in the study group compared to the control group (P<0.001 for all) and no significant difference was detected between the two groups in MCV change (P=0.122). Conclusion: Endurance training program improved homocysteine and vitamin B12 biomarkers but not as conventional therapy and significantly improved gait speed.
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