|
|
 |
| |
|
|
|
AND-NOT logic framework for steady state analysis of Boolean network models |
|
|
|
PP: 1263-1274 |
|
|
|
Author(s) |
|
|
|
Alan Veliz-Cuba,
Kristina Buschur,
Rose Hamershock,
Ariel Kniss,
Esther Wolff,
Reinhard Laubenbacher,
|
|
|
|
Abstract |
|
|
| In this paper we propose the class of AND-NOT networks for modeling biological systems and show that it provides
several advantages. Some of the advantages include: Any finite dynamical system can be written as an AND-NOT network with similar
dynamical properties. There is a one-to-one correspondence between AND-NOT networks, their wiring diagrams, and their dynamics.
Results about AND-NOT networks can be stated at the wiring diagram level without losing any information. Results about AND-NOT
networks are applicable to any Boolean network. We apply our results to a Boolean model of Th-cell differentiation. |
|
|
|
|
|
|
|
