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Evidence based Decision and Meta-Analysis with Applications in Cancer Research Studies |
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PP: 815-822 |
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doi:10.18576/amis/100301
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Author(s) |
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Shahjahan Khan,
Suhail A R Doi,
M Ashraf Memon,
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Abstract |
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| In the age of evidence based decision making through a systematic review of the literature, statistical meta-analysis has been
extensively used to synthesise published summary data on a particular topic of interest from a number of independent studies in order to
make credible and scientifically valid conclusions. The main objective is to estimate the common effect size as a pooled statistic for any
selected outcome variables from the relevant data. There are several issues concerning the quality and type of the published summary
statistics and inherent heterogeneity among the estimates of the effect size across the studies. This paper covers several estimators of the
common effect size and some of their major impacts in meta-analysis through redistribution of weights to the individual studies. Some
examples from recent literature on cancer research studies are used to illustrate the alternative estimators and discuss their usefulness
in analysing data from randomised controlled trials in medicine. |
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