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Archives of Biological and Biomedical Research
An International Journal



Alterations of Telomerase reverse transcriptase and its promoter in the melanocytic lesions of the skin

Prof. Mahmoud Rezk Abdelwahed Hussein,
Abstract :
Malignant melanoma is a deadly neoplasm, which has recently shown a dramatic increase in global incidence. It evolves and progresses through a multistep process during which there is a sequential transition from the precursor lesions to early indolent stages and finally to the late aggressive stages. Tumorigenesis is related to telomerase alterations. Although these changes were recently examined in the advanced stages of melanoma, similar investigations in the precursor lesions (some dysplastic nevi) as well as in the earliest stages of these lesions are lacking. An understanding of these changes will provide valuable insights into the pathogenesis of these tumors. It may also have some therapeutic ramifications.


Langerhans cell histiocytosis of the ear

Prof. Mahmoud R. Hussein, Dr. Usama M Rashad, Dr. Al Hussein Awad Ali,
Abstract :
Langerhans cell histiocytosis (LCH) is a rare neoplastic lesion characterized by accumulation of cells having major phenotypic features of skin Langerhans cells. It usually affects young children but rare cases were also reported in adults. The clinical spectrum of LCH includes Letterer–Siwe disease, Hand–Schüller–Christian disease, eosinophilic granuloma, Langerhans cell sarcoma as well as intermediate and poorly elucidated forms. Here we address the clinicopathologic features and histogenesis of this condition.


Expression of C-KIT Tyrosine Kinase Receptor, Epidermal Growth Factor, and p53 Proteins in the epithelial and mesenchymal cells of Hepatoblastoma: Preliminary Findings

Prof. Mahmoud R. A. Hussein, Prof. Eman E Abu-Dief,
Abstract :
Background: Overexpression of receptor-type protein tyrosine kinases (PTKs) and alterations of p53 are well known events in neoplastic cells and are associated with an aggressive tumor phenotype. To date, our knowledge about PTKs and p53 expression in the neoplastic cells (epithelial and mesenchymal cells) of hepatoblastoma is incomplete. Objectives: This study tries to address this issue and test the hypothesis that “PTKs receptors and p53 protein expression is altered in hepatoblastoma”. Materials and methods: The expression patterns of PTKs (epidermal growth factor receptor and KIT) and tumor suppressor p53 protein) was examined in a case of hepatoblastoma using specific antibodies and immunoperoxidase staining methods. Results: Cytoplasmic PTKs and p53 protein expressions were seen in both glandular and mesenchymal component of the hepatoblastoma. Some nuclear p53 protein expression was also seen. Conclusions: The expression of these proteins in hepatoblastoma suggests their possible roles in histogenesis of these lesions.


Bladder Wall Thickness in men with lower urinary tract symptoms - Preliminary results

Prof. Fawzy Farag, Dr. Mohamed Elbadry, Dr. Mohammed Saber, Dr. Abdelbasset Badawy, Prof. John Heesakkers,
Abstract :
Aim To determine the relationship between bladder wall thickness (BWT) and lower urinary tract symptoms (LUTS). Material and Methods Male patients with LUTS completed the International Prostate Symptom Score (IPSS) sheet. Prostate size was measured using transrectal ultrasound. Urodynamic assessment was performed in all patients. Transabdominal ultrasound was used in measurement of BWT during filling cystometry at 250 ml using a 5 MHz abdominal transducer. Results A total of 72 patients were included in final analysis. A significant correlation was found between BWT and Age (r = 0.44; p <0.0001), IPSS (r = 0.3; p<0.01), and voided volumes (r = 0.45; p<0.0001). Conclusions Increase in BWT can be related to development of LUTS in men with benign prostatic enlargement.

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